Video course abdominal ultrasound
Examination of the abdominal vessels – Superior mesenteric artery, colour Doppler imaging
Author: Prof. Dr. Christoph F. Dietrich ©2019 Falk Foundation e.V., Freiburg. All rights reserved.
Please switch on your loudspeakers!Link to Falk Mediacenter
Latest research in brief:Bowel
Schreiber S et al, Gastroenterology. 2021;160(7):2340–53
Subcutaneous infliximab for inflammatory bowel disease: The subcutaneous infliximab biosimilar CT-P13 was non-inferior to intravenous application during maintenance therapy with regard to efficacy, safety and immunogenicity.
Feagan BG et al, Lancet. 2021;397(10292):2372–84
Filgotinib as induction and maintenance therapy for ulcerative colitis: Filgotinib (200 mg/day) was well tolerated and efficacious in inducing and maintaining remission compared with placebo in a phase 2b/3 trial program (SELECTION).
Kennedy NA et al, Gut. 2021; in press
Immunogenicity of SARS-CoV2 vaccines in patients with inflammatory bowel diseases an infliximab therapy: In a British cohort, infliximab was associated with attenuated immunogenicity to a single dose of the BNT162b2 and ChAdOx1 nCoV-19 vaccines. Vaccination after SARS-CoV2 infection or a second dose of vaccine led to seroconversion in most patients. The second vaccine dose should therefore not be delayed.
Choi J et al, Hepatology. 2021;73(6):2155–66
Chronic hepatitis B virus (HBV) infection: A recent South Korean study reveals that risks of hepatocellular carcinoma (HCC) and clinical events do not differ significantly between spontaneous and therapy-induced HBsAg seroclearance. However, the annual HCC risk exceeds the recommended cut-off for HCC surveillance even after HBsAg seroclearance, suggesting that continued HCC surveillance is required. Future studies need to clarify whether these Asian study results also apply to e.g. European cohorts.
Collins CJ et al, Gastroenterology. 2021;160(7):2367–82.e1
Wilson disease: Diagnosis of Wilson disease based on laboratory or genetic parameters is often difficult. A current study shows that the determination of ATP7B peptides is highly effective in the diagnosis of Wilson disease (sensitivity 91.2%, specificity 98.1%, positive predictive value 98%, negative predictive value 91.5%). This also applied to Wilson disease patients with normal ceruloplasmin levels or ambiguous genetic results.
Simon TG et al, Gut. 2021;70(7):1375–82
Non-alcoholic fatty liver disease (NAFLD): A nationwide Swedish cohort study shows that all histological NAFLD stages are associated with significantly increased overall mortality with the risk increasing with stage (simple steatosis – steatohepatitis – fibrosis – cirrhosis). Most of this excess mortality was due to extrahepatic cancer and cirrhosis, while the contributions from cardiovascular disease and hepatocellular carcinoma were lower.
Janjigian YY et al, Lancet. 2021;398(10294):27–40
Checkpoint inhibition as first-line therapy for advanced gastric, gastroesophageal junction and esophageal adenocarcinoma: Nivolumab plus chemotherapy resulted in superior overall survival as well as progression-free survival as compared to chemotherapy alone in a phase 3 trial and represents a new standard of first-line treatment for these patients.
Kelly CP et al, Gastroenterology. 2021;161(1):66–80.e8
Novel therapy for celiac disease (1): In a proof-of-concept study, immune modulating gliadin nanoparticles (TAK-101) were well tolerated and prevented gluten-induced immune activation in patients with celiac disease. These findings suggest that antigen-specific tolerance was induced indicating that TAK-101 may represent a promising approach to treat celiac disease.
Schuppan D et al, N Engl J Med. 2021;385(1):35–45
Novel therapy for celiac disease (2): In a proof-of-concept study, therapy with ZED1227, an oral inhibitor of transglutaminase 2, attenuated gluten-induced duodenal mucosal damage in patients with celiac disease.
Ramchandani M et al, Gastroenterology. 2021;161(1):185–95
Endoscopic therapy of benign biliary strictures secondary to chronic pancreatitis: Efficacy and safety of endotherapy using fully covered metal stents is non-inferior to repeated stenting with plastic. However, metal stents were associated with fewer interventions.
Online Live Event
Abdominal Imaging in Gastroenterology and Hepatology
On-demand version of the Online Live Event from June 2, 2021 Duration: ca. 2:22 hours • The evolution of the role of liver stiffness measurement in hepatology, including spleen stiffness • Role of ultrasound in Crohn’s disease • Imaging in acute and chronic pancreatitis • Liver specific MRI contrast agents: what we know and what we still would like to know
Robert J. de Knegt, Rotterdam (The Netherlands)
Marco Bruno, Rotterdam (The Netherlands) Gabriel P. Krestin, Rotterdam (The Netherlands) Michael P. Manns, Hannover (Germany) Maarten G.J. Thomeer, Rotterdam (The Netherlands)Link to Falk Mediacenter
Current Falk literature:
Liver Function Tests and Liver Scores
Relevance, Interpretation, Algorithms, and Disease Specifics
Authors: A. Canbay, J. Best, M. Özçürümez