Falk Gastro Info 7/2022

A simple and highly reproducible index for histologial remission in ulcerative colitis based on chromoendoscopy: The simple “Paddington International virtual ChromoendoScopy ScOre“ (PICaSSO) histological remission index exhibited the highest correlation with endoscopic activity and clinical outcomes and may be used in artificial intelligence algorithms to predict histological remission.

No weight gain related to TNF inhibitor therapy: Weight gain in patients with inflammatory bowel disease treated with TNF inhibitors was unlikely to be due to an effect from TNF inhibitor therapy in a nationwide observational study from Denmark.

Non-alcoholic fatty liver disease (NAFLD) and risk for hepatocellular carcinoma (HCC): Role of diabetes medications and glycemic control: A large American retrospective cohort study shows that metformin is associated with a reduced HCC risk in NAFLD patients, while a combination therapy of insulin and other oral antidiabetics is associated with an increased risk. Adequate glycemic control is also linked to a significantly reduced HCC risk.

A recent case simulation study confirms the value of liver biopsy in diagnosis of drug-induced liver injury (DILI): The study shows that liver histology is particularly helpful in cholestatic or equivocal cases of DILI and shifts the evaluation in "possible" or "probable" DILI cases towards "certain/very likely" or "unlikely".

Safe pregnancy after liver transplantation: Evidence from a multicenter Italian collaborative study: A recent multicenter collaborative Italian study confirms that pregnancies in liver transplant recipients are associated with an increased risk of maternal complications and premature births, however have a good outcome.

No impact of gluten on gastrointestinal complaints: Compared to placebo, adding gluten to the diet did not induce gastrointestinal complaints or worsened mental health in adolescents recruited from a population-based cohort.