Dr. Falk Video report
EoE – State of the Art – PART 4
The most important facts summarized:
- Topical corticosteroids are efficient in inducing a clinico-histological remission in EoE patients
- Topical corticosteroids are more efficient in maintaining clinico-histological remission in EoE patients than placebo
- Topical corticosteroids significantly reduce the risk of a bolus impaction in EoE patients compared to placebo
- Withdrawal of topical corticosteroids in patients with deep remission is leading to a relapse in around 80% of the cases
- Most EoE-patients need a long term treatment for their disease, for example with topical corticosteroids
Video-Report – PART 4 of the Satellite Symposium „EoE – State of the Art“, which took place during the ueg week 2018 in Vienna (Austria). Prof. Dr. Stephan Miehlke from Hamburg (Germany) talked about “Therapeutic strategies” of Eosinophilic Esophagitis.
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Latest research in brief:
Bowel
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Ungaro RC et al, Gut. 2019;68(6):977–84
Exit strategies for 5-aminosalicylates (5-ASA) in patients with ulcerative colitis: Analysis of 2 national patient cohorts reveals that stopping 5-ASA in patients starting tumor necrosis factor inhibitors does not increase the risk of adverse disease outcomes.
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Zhou QQ et al, Gut. 2019;68(6):996–1002
Glutamine supplements to treat postinfectious irritable bowel syndrome with diarrhea (IBS-D): In patients with IBS-D with intestinal hyperpermeability, oral dietary glutamine supplementation profoundly and safely reduced all major IBS-related end points as compared to placebo in a trial involving 106 patients.
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Bernstein CN et al, Gastroenterology. 2019;156(8):2190–7.e10
Impact of early life events on the risk of inflammatory bowel disease (IBD): Results from the Manitoba cohort suggest that infections within the first year of life, socioeconomic factors and a diagnosis of IBD of the mother are associated with an increased risk to develop IBD in the future. These factors may interfere with the development of the intestinal microbiota.
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Liver Biliary Tracts
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Yan J et al, Hepatology. 2019;69(6):2414–26
Non-alcoholic fatty liver disease (NAFLD): In patients with type 2 diabetes mellitus and NAFLD, liraglutide and sitagliptin in combination with metformin reduced body weight, intrahepatic lipid and visceral adipose tissue; insulin glargine had no similar effect.
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Kaplan DE et al, Gastroenterology. 2019;156(6):1693–706.e12
Liver cirrhosis: In patients with liver cirrhosis, hypercholesterolemia indicates well-preserved liver function as is associated with decreased mortality. Nonetheless, statin exposure of these patients may be associated with an independent decrease of mortality.
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Baumeister SE et al, J Hepatol. 2019;70(5):885–92
Hepatocellular carcinoma (HCC): A recent analysis of a large epidemiological study demonstrates an inverse association between physical activity and HCC risk. This inverse association may be mediated by obesity.
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Oesophagus Stomach Duodenum
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Radaelli F et al, Gut. 2019;68(6):969–76
Periendoscopic management of direct oral anticoagulants: A prospective cohort study reveals that high-risk procedures are associated with a substantial risk of bleeding which is further increased by heparin bridging.
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Xie Y et al, BMJ. 2019;365:l1580
Risks associated with chronic proton-pump inhibitor (PPI) therapy: Taking PPI was associated with a small excess of mortality related to cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. A similar burden was also observed in patients without an indication for PPI use. Therefore, the indications for PPI prescription should be questioned critically.
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Chu DK et al, Lancet. 2019;393(10187):2222–32
Oral immunotherapy for peanut allergy: A systematic review and meta-analysis reveals that available oral immunotherapy regimens considerably increase allergic and anaphylactic reactions as compared to avoidance or placebo, despite effectively inducing desensitization. Safer therapy approaches are therefore needed.
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Pancreas
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Paiella S et al, Am J Gastroenterol. 2019;114(4):665–70
Surveillance of individuals at high risk of pancreatic cancer: First round of screening by magnetic resonance imaging or endosonography in 187 individuals revealed a high rate of malignancy amounting to 2.6%.
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International Symposia and Workshops
Symposium 215
IBD: From Diagnosis to Therapy
July 5–6, 2019, St. Petersburg, Russia
Park Inn by Radisson, Pribaltiyskaya, Ul. Korablestroiteley 14, 199226 St. Petersburg, Russia
Registration
Online registration
Symposium 216
Building Bridges in IBD
September 13–14, 2019, Brussels, Belgium
Square Brussels Convention Centre, Glass Entrance, Mont des Arts/Kunstberg, 1000 Brussels, Belgium
Registration
Online registration
Ulcerative colitis
Crohn’s disease
An overview of the diseases and their treatment
Authors: J. Schölmerich, G. Rogler, H. Herfarth
(60 pages)
S80e