Falk Gastro Info 7/2018

Video

Examination of the hepatobiliary system: Examination of the gallbladder in supine position

Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.
©2017 Falk Foundation e.V., Freiburg. All rights reserved.

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Latest research in brief:

Bowel

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Bisschops R et al, Gut. 2018;67(6):1087-94

Chromoendoscopy versus narrow band imaging in ulcerative colitis: A controlled trial reveals no significant differences in detection of colitis-associated neoplasia.

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Donnachie E et al, Gut. 2018;67(6):1078-86

Risk factors for irritable bowel syndrome (IBS): Population level data reveal that patients with gastrointestinal infections have an approx. 2- to 4-fold increased risk to develop IBS and chronic fatigue syndrome. Preexisting psychological disorders and female gender are additional risk factors.

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Brenner DM et al, Am J Gastroenterol. 2018;113(5):735-45

Novel therapy for patients with irritable bowel syndrome with constipation (IBS-C): Results from 2 phase 3 trials indicate that the guanylate cyclase C activator plecanatide significantly improves abdominal pain and constipation symptoms in IBS-C patients with minimal side effects and high tolerability.

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Liver Biliary Tracts

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El-Sherif O et al, Gastroenterology. 2018;154(8):2111-21.e8

Hepatitis C: Clinical benefit of direct-acting antiviral therapy in decompensated cirrhosis remains controversial. A current study has identified 5 baseline parameters associated with a reduction in Child-Pugh-Turcotte to class A after therapy: body mass index, encephalopathy, ascites, serum-alanine aminotransferase and serum-albumin. Based on these parameters, an easy-to-use score has been developed to predict the potential benefit of antiviral therapy.

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Åberg F et al, Hepatology. 2018;67(6):2141-9

Metabolic syndrome and alcohol consumption: A current population-based study reveals that not only alcohol “risk” use is a significant risk factor for severe liver diseases. Indeed, even when average alcohol consumption is within the limits currently defining non-alcoholic fatty liver disease, the risk for severe liver disease is substantially increased.

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Ali AH et al, Hepatology. 2018;67(6):2338-51

Primary sclerosing cholangitis (PSC): A study by the Mayo Clinic Rochester demonstrates that surveillance for hepatobiliary carcinoma (cholangiocellular, hepatocellular and gallbladder carcinoma) by abdominal imaging, carbohydrate antigen 19-9 and alpha-fetoprotein substantially improves outcomes, including survival, in patients with PSC.

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Oesophagus Stomach Duodenum

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Yeomans ND et al, Aliment Pharmacol Ther. 2018;47(11):1453-63

Gastrointestinal events in arthritis patients treated with non-steroidal anti-inflammatory drugs co-treated with esomeprazole: Clinically significant complications are rare (< 1%). However, celecoxib has a better safety profile than ibuprofen or naproxen. [x_button type="transparent" shape="pill" size="regular" block="false" circle="false" icon_only="false" href="http://www.drfalkpharma.com/index.php?L=1&id=27268#c37294" title="" target="blank" info="none" info_place="top" info_trigger="hover" info_content=""]Link to text[/x_button] Text: Francavilla R et al, Am J Gastroenterol. 2018;113(3):421-30

Non-celiac gluten sensitivity (NCGS) in children: A double-blind trial demonstrates the existence of NCGS in children. Although its prevalence was low, double-blind gluten challenge was useful to confirm or rule out the diagnosis.

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Cats A et al, Lancet Oncol. 2018;19(5):616-28

Postoperative management of patients with resectable gastric cancer: Postoperative chemoradiotherapy did not improve overall survival compared with postoperative chemotherapy in patients with resectable gastric cancer treated with adequate preoperative chemotherapy and surgery.

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Pancreas

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Kirkegård J et al, Gastroenterology. 2018;154(6):1729-36

Risk factors for pancreatic cancer: A nationwide population-based cohort study from Denmark reveals that patients with acute pancreatitis have an approx. 2-fold increased long-term risk to develop pancreatic cancer. Absolute cancer risk following acute pancreatitis was 0.7% and 0.87% after 2 and 5 years, respectively.

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International Symposia and Workshops

Symposium 211

XXV International Bile Acid Meeting:
Bile Acids in Health and Disease 2018

July 6-7, 2018, Dublin, Ireland
Clayton Hotel Burlington Road, Upper Leeson Street, D04 A318 Dublin 4, Ireland

Program

Registration

Online registration

Symposium 212

IBD and Liver: East Meets West

September 7-8, 2018, Kyoto, Japan
Kyoto Hotel Okura, Kawaramachi-Oike, Nakagyo-ku, Kyoto 604-8558, Japan

Program