Video
Enquired…
Prof. Dr. Britta Siegmund, Berlin
- How closely has the microbiome of the gut been examined?
- What is the goal of future research?
- What are the possible approaches for the treatment of IBD?
Video report to the discussion with Prof. Dr. Britta Siegmund, Berlin, at Symposium 209 “IBD 2017 – Therapeutic and Biological Barriers”, October 6-7, 2017 in Berlin.
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Latest research in brief:
Bowel
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Chaparro M et al, Am J Gastroenterol. 2018;113(3):396-4030
Long-term safety of in utero exposure with anti-TNF drugs for inflammatory bowel disease: Long-term results of the TEDDY study reveal that children with anti-TNF exposure do not have an increased risk for infections during early childhood.
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Grothey A et al, N Engl J Med. 2018;378(13):1177-88
Adjuvant chemotherapy for stage III colon cancer: In a pooled analysis of 6 randomized trials with FOLFOX or CAPOX, treatment duration of 3 months failed to demonstrate non-inferiority compared to therapy for 6 months. However, in patients receiving CAPOX or subgroups with better prognosis, 3 months of therapy was equally effective as 6 months.
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D’Haens G et al, Gastroenterology. 2018;154(5):1343-51.e1
Algorithms to tailor infliximab dosing for Crohn’s disease: An algorithm of dose escalation based on clinical symptoms, biomarkers and infliximab trough levels was not superior to symptom-based therapy escalation to induce steroid-free and endoscopic remission.
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Liver Biliary Tracts
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Boerekamps A et al, Clin Infect Dis. 2018;66(9):1360-5
Hepatitis C: HIV-positive men who have sex with men are at high risk for acute hepatitis C virus (HCV) infection. A current Dutch study demonstrates that unrestricted access to direct-acting antivirals leads to a decline in the incidence of acute HCV infection in this high-risk group.
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Murillo Perez CF et al, Hepatology. 2018;67(5):1920-30
Primary biliary cholangitis (PBC): Over last 4 decades, age at diagnosis increased substantially (from 47 to 57 years). At the same time, disease severity decreased (liver function tests, histology, decompensation rate, 10-year transplant-free survival) while treatment response to ursodeoxycholic acid increased.
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Tzartzeva K et al, Gastroenterology. 2018;154(6):1706-18.e1
Surveillance of hepatocellular carcinoma (HCC): The benefit of alpha-fetoprotein (AFP) in HCC surveillance is currently under debate. A current meta-analysis, however, suggests that AFP measurement in addition to ultrasound significantly increases the sensitivity in early HCC detection.
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Oesophagus Stomach Duodenum
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Choi IJ et al, N Engl J Med. 2018;378(12):1085-95
Helicobacter pylori and gastric cancer: H. pylori eradication therapy after endoscopic resection of early gastric cancer decreases the incidence of metachronous gastric cancer and improves mucosal gland atrophy.
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Nguyen LH et al, Gastroenterology. 2018;154(5):1290-7.e1
Proton-pump inhibitor (PPI) therapy and risk of stroke: Analysis of data from 2 large prospective cohorts reveals that PPI use is not associated with increased risk of ischemic stroke after accounting for indications of PPI use.
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Laine L et al, Am J Gastroenterol. 2018;113(3):358-66
Risk stratification of upper gastrointestinal bleeding: Bloody emesis is not associated with more severe bleeding or higher mortality than coffee-grounds emesis. However, additional melena correlates with worse outcomes, which should be considered in decisions regarding timing of endoscopy.
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Pancreas
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Khalaf N et al, Gastroenterology. 2018;154(5):1380-90.e5
Chemoprevention of pancreatic cancer: Regular use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs is not associated with risk of incident pancreatic cancer.
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International Symposia and Workshops
Symposium 211
XXV International Bile Acid Meeting:
Bile Acids in Health and Disease 2018
July 6-7, 2018, Dublin, Ireland
Clayton Hotel Burlington Road, Upper Leeson Street, D04 A318 Dublin 4, Ireland
Registration
Online registration
Current Falk literature:
GastroScope
Symposium 209
IBD 2017 – Therapeutic and Biological Barriers
Berlin (Germany)
October 6 – 7, 2017
Issue 01/2018
(22 Seiten)
GS209e