Falk Gastro Info 5/2016

Video

Video course abdominal ultrasound

Lymph node

Mesenterium

Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.

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Link to Falk Mediacenter

Latest research in brief:

Bowel

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Lin EC et al, Clin Gastroenterol Hepatol. 2016;14(2):203–8

Small-bowel bacterial overgrowth Scintigraphy demonstrates high rates of false-positive results from glucose breath tests.

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Kennedy NA et al, Aliment Pharmacol Ther. 2016;43(8):910–23

Inflammatory bowel disease: Approx. one-third of IBD patients flare within 12 months of withdrawal of anti-TNF therapy for sustained remission.

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Wardle J et al, Lancet. 2016;387(10020):751–9

Colon cancer screening: Only moderate effects of evidence-based strategies to reduce the socioeconomic gradient of uptake in the English Bowel Cancer Screening Program.

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Liver Biliary Tracts

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Carbone LJ et al, J Gastroenterol Hepatol. 2016;31(1):23–31

Non-alcoholic steatohepatitis (NASH): A current meta-analysis indicates that incretin-based pharmacotherapy (GLP-1 receptor agonist and DPP-4 inhibitors) may induce a significant reduction of liver enzymes (alanine aminotransferase, ALT) and an improvement of histological criteria. This meta-analysis was limited however, by the fact that only 4 of 1357 screened studies could be included due to the defined criteria.

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Stokkeland K et al, Liver Int. 2016;36(1):76–83

Autoimmune hepatitis: Autoimmune hepatitis is associated with a complicated course of pregnancy, including gestational diabetes, preterm birth, and of low-birth-weight child. In the current study, however, there was no increased risk for pre-eclampsia, congenital malformation, or neonatal mortality.

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Ding NS et al, Liver Int. 2016;36(2):240–5

Cirrhosis: Increasing use of transient elastography identifies an increasing number of patients with Child-Pugh A cirrhosis. Many of these patient do not suffer from portal hypertension, thus the benefit of screening gastroscopy in these patients is a matter of debate. The current study indicates that patients with a liver stiffness ≤ 25 kPa plus a platelet count ≥ 100 are unlikely to have high-risk gastroesophageal varices and may thus be spared from screening gastroscopy.

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Oesophagus Stomach Duodenum

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Pohl H et al, Gut. 2016;65(2):196–201

Barrett’s esophagus (BE): Cancer risk strongly correlates with BE length, suggesting that surveillance endoscopies for patients with short/ultra-short segment BE are likely of limited value.

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Safroneeva E et al, Gastroenterology. 2016;150(3):581–90.e4

Eosinophilic esophagitis: Symptoms have modest accuracy in detecting endoscopic and histologic remission.

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Tack J et al, Clin Gastroenterol Hepatol. 2016;14(3):385–92.e4

Functional dyspepsia with weight loss: Pilot trial reveals relative efficacy of mirtazapine.

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