Falk Gastro Info 4/2017

Video

Video course abdominal ultrasound

Examination of the liver – Liver hilum: anatomy

Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.

© 2017 Falk Foundation e.V., Freiburg. All rights reserved.

 

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Latest research in brief:

 

Bowel

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Major G et al, Gastroenterology. 2017;152(1):124–33.e2

Pathogenesis of irritable bowel syndrome: Colon hypersensitivity to distension, rather than excessive gas production produces carbohydrate-related symptoms in individuals with irritable bowel syndrome.

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Ott SJ et al, Gastroenterology. 2017;152(4):799–811.e7

Therapy of Clostridium difficile infection: This pilot study suggests that transfer of sterile filtrates from donor stool may be sufficient to restore normal stool habits and eliminate symptoms of recurrent C. difficile infection.

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van de Wall BJM et al, Lancet Gastroenterol Hepatol. 2017;2(1):13–22

Surgery versus conservative treatment for recurrent and ongoing left-sided diverticulitis: Elective sigmoidectomy results in better quality of life than conservative management after 6 months.

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Liver Biliary Tracts

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van der Ree MH et al, Lancet. 2017;389(10070):709–17

Hepatitis C: In a double-blind, randomized, placebo-controlled phase 1b study, the miR-122 antagonist RG-101 displayed a strong antiviral effect in all patients after a single subcutaneous injection. 3 of 32 patients reached sustained virological response (negative HCV PCR after 76 weeks) upon the single injection.

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Samur S et al, Hepatology. 2017;65(3):920–8

Primary biliary cholangitis (PBC): According to a current simulation model, obeticholic acid is a promising new therapy to substantially improve the long-term outcomes of PBC patients. Using a willingness-to-pay threshold of $100,000/quality-adjusted life year, however, pricing below $18,450/year is needed.

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Prajapati R et al, Eur J Gastroenterol Hepatol. 2017;29(4):448–55

Decompensated cirrhosis: A current study demonstrates that granulocyte colony-stimulating factor (GCSF) improves survival and clinical course in patients with decompensated cirrhosis. The optimal treatment regimen (duration and cycles) needs to be defined in further studies.

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Oesophagus Stomach Duodenum

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Lam JR et al, Gastroenterology. 2017;152(4):821–9.e1

Side effects of gastric acid suppressing therapies: Among patients without known risk factors for iron deficiency, gastric acid inhibitor use for ≥ 2 years was associated with an increased subsequent risk of iron deficiency.

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Schauer PR et al, N Engl J Med. 2017;376(7):641–51

Bariatric surgery versus intensive medical therapy for diabetes: Combination of bariatric surgery and medical therapy is more effective than medical therapy alone in decreasing/resolving hyperglycemia.

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Choung RS et al, Gastroenterology. 2017;152(4):830–9.e5

Epidemiology of undiagnosed celiac disease (CD): Prevalence of undiagnosed CD amounts to 1.1%, but disease appears to be clinically silent and remains undetected in most of the cases.

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Pancreas

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Masamune A et al, Gut. 2017;66(3):487–94

Long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis: Corticosteroid therapy for 3 years may decrease disease relapses compared to discontinuation of steroid therapy after 26 weeks.

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International Symposia and Workshops

Symposium 207

Gut Microbiome and Mucosal or Systemic Dysfunction: Mechanisms, Clinical Manifestations and Interventions D

May 19 – 20, 2017, Brisbane, Australia
Brisbane Convention & Exhibition Centre, Merivale St & Glenelg Street, South Brisbane, QLD 4101, Australia

Program

 

Registration

 

Online registration

 
Current Falk literature:
GastroScope – Congress news from Falk Foundation e.V.
Symposium 205

New Treatment Targets in Gut and Liver Diseases

Lucerne (Switzerland), October 21–22, 2016
Issue 03/2016
(22 pages)
GS205e

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http://newsletter.drfalkpharma.de/FGI_4-17/GS205e.jpg

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