Falk Gastro Info 4/2021

Video course abdominal ultrasound

Examination of abdominal vessels – Iliac vessels

Author: Prof. Dr. Christoph F. Dietrich ©2019 Falk Foundation e.V., Freiburg. All rights reserved.

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Latest research in brief:


Rutter MD et al, Gut. 2021;70(3):537–43
Impact of Covid-19 pandemic on endoscopic activity and cancer detection: A national analysis in the UK revealed that endoscopic activity in spring 2020 was reduced to 12% of pre-Covid-19 levels and resulted in a decrease of tumor diagnoses by 58%.

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Jaung R et al, Clin Gastroenterol Hepatol. 2021;19(3):503–10.e1
Antibiotics for uncomplicated diverticulitis:): Antibiotic treatment did not affect length of hospital stay, rates of adverse events and readmission rates after 7 or 30 days as compared to placebo in a randomized placebo-controlled trial comprising 180 patients. These results provide strong evidence that antibiotic therapy may be safely omitted in patients with uncomplicated diverticulitis.

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Bager P et al, Aliment Pharmacol Ther. 2021;53(1):79–86
Therapy of chronic fatigue in patients with quiescent inflammatory bowel diseases (IBD): This randomized cross-over pilot trial with 40 CED patients currently in remission showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue as compared to placebo with only few and mild side effects.

Link to text Liver Biliary Tracts

Page K et al, N Engl J Med. 2021;384(6):541–9
NoHepatitis C virus (HCV):A current, highly anticipated vaccination study on the prophylactic vaccination against HCV using a viral vector vaccine with a prime boost regimen showed that this vaccination regimen induced T-cell responses against HCV and decreased HCV viremia in infected people. Unfortunately, however, the vaccination regime was unable to prevent chronic HCV infection.

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Vilar-Gomez E et al, Clin Gastroenterol Hepatol. 2021;19(1):136–45.e6
AcuNon-alcoholic steatohepatitis (NASH) and cirrhosis: A recent cohort study confirms the high benefits of metformin in patients with NASH, type 2 diabetes and Child A cirrhosis. Especially in patients with increased hemoglobin A1c, metformin significantly reduced the risk of death, decompensation of cirrhosis and hepatocellular carcinoma.

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China L et al, N Engl J Med. 2021;384(9):808–17
Decompensated cirrhosis: In recent years, human albumin substitution in patients with advanced cirrhosis has been the subject of controversy. A current randomized study in patients who were hospitalized with decompensated cirrhosis showed a negative result in this regard: Albumin infusions to increase the albumin level to a target of ≥ 3 g/dl were not superior to the current standard treatment.

Link to text Oesophagus Stomach Duodenum

Gouriou C et al, Aliment Pharmacol Ther. 2021;53(6):688–95
Outcomes of upper gastrointestinal bleeding (GI) in patients taking oral anticoagulants: Novel oral anticoagulants do not alter the outcomes of upper GI bleeding as compared to vitamin K antagonists in a prospective nationwide study from France. Comorbidities and occurrence of bleeding during hospitalization were the most important risk factors associated with adverse outcomes.

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Carlin JL et al, Gastroenterology. 2021;160(1):76–87.e4
Therapy of patients with diabetic or idiopathic gastroparesis: The tachykinin receptor 1 antagonist tradipitant resulted in a statistically and clinically meaningful improvement in nausea and vomiting as compared to placebo.

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Zagari RM et al, Am J Gastroenterol. 2021;116(2):289–95
Tumor risk in achalasia patients: Patients with achalasia have an excess risk of developing both, squamous cell carcinoma and adenocarcinoma of the esophagus. However, the absolute incidence of esophageal cancer is rather low in this population.

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Huang J et al, Gastroenterology. 2021;160(3):744–54136–44
Worldwide burden of, risk factors for, and trends in pancreatic cancer: Analysis of the global GLOBOCAN initiative revealed increasing incidence and mortality trends in pancreatic cancer, especially in women and populations 50 years or older, but also in younger individuals.

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Abdominal Imaging in Gastroenterology and Hepatology

June 2, 2021
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Current Falk literature:

Diagnosis of Viral Hepatitis

(36 pages)