Dr. Falk Video report
Examination of the kidneys:
Right kidney, transversal (not shown for the left side)
Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.
©2019 Falk Foundation e.V., Freiburg. All rights reserved.
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Latest research in brief:
Bowel
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Sandborn WJ et al, Gastroenterology. 2020;158(3):562–72.e12
Subcutaneous vedolizumab for patients with ulcerative colitis: Subcutaneous and intravenous vedolizumab formulations are equally effective as maintenance therapy in patients with moderately to severely active ulcerative colitis who had clinical response to intravenous vedolizumab induction therapy.
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WAbu-Sbeih H et al, J Clin Oncol. 2020;38(6):576–83
Immune checkpoint inhibitor therapy in patients with preexisting inflammatory bowel disease (IBD): Preexisting IBD increases the risk of severe gastrointestinal adverse events in patients treated with checkpoint inhibitors.
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Bleijenberg AGC et al, Gut. 2020;69(1):112–21
Surveillance of patients with serrated polyposis syndrome: Risk stratification based on polyp burden significantly reduced the colonoscopy burden in a prospective 5-year international cohort study.
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Liver Biliary Tracts
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CBrown RS Jr et al, J Hepatol. 2020;72(3):441–9
Hepatitis C virus (HCV): A current phase 3b trial demonstrates that in treatment-naive patients with compensated cirrhosis, glecaprevir/pibrentasvir for 8 weeks leads to high sustained virological response rates, independent of HCV genotype.
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Schmidt T et al, Clin Gastroenterol Hepatol. 2020;18(1):226–33.e3
Autoimmune hepatitis: Almost 20% of patients with autoimmune hepatitis older than 50 years have osteoporosis. Older age, duration of corticosteroid use, low body mass index, and liver fibrosis are independent risk factors for bone loss.
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Dueñas E et al, Dig Liver Dis. 2020;52(1):79–83
Band ligation of esophageal varices: Post-banding ulcer bleeding is an uncommon but severe complication of esophageal banding. Patients with hepatocellular carcinoma, poor liver function and a low beta-blocker dose have higher risk of post-banding ulcer bleeding. Active bleeding at endoscopy is associated with high mortality, thus aggressive treatment should be considered.
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Oesophagus Stomach Duodenum
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Kumar S et al, Gastroenterology. 2020;158(3):527–36.e7
Helicobacter pylori infection and gastric cancer risk: A retrospective study of 371.813 American veterans indicates that the risk to develop gastric cancer within 20 years following the diagnosis of H. pylori infection is well below 1%. Racial and ethnic minorities as well as smokers have an increased tumor risk which can be reduced by successful eradication therapy.
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Azad TD et al, Gastroenterology. 2020;158(3):494–505.e6/em>
Circulating tumor DNA for detection of residual disease and tumor progression of esophageal cancer: Cell-free DNA in blood samples from patients who underwent chemoradiotherapy is associated with tumor progression, metastasis and disease-specific survival and may be used to identify patients at high risk for tumor progression.
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PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group et al, JAMA. 2020;323(7):616–26
Stress ulcer prophylaxis among ICU patients receiving invasive mechanical ventilation: In a randomized trial comprising 26,771 patients, stress ulcer prophylaxes with proton-pump inhibitors or histamine-2 receptor blockers was associated with comparable rates of hospital mortality, upper gastrointestinal bleeding, infections with Clostridioides difficile and ICU/hospital length of stay.
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Pancreas
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Issa Y et al, JAMA. 2020;323(3):237–47
Therapy algorithms for chronic pancreatitis: Results of a randomized trial indicate that early surgery compared with an endoscopy-first approach results in lower pain intensity over 18 months.
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Current Falk literature:
Ultrasound of the Liver
Malignant Liver Lesions
Author: D.-A. Clevert
(93 pages)
U42-2e