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Video course abdominal ultrasound
Examination of the Liver: Recessus costodiafragmaticus lateralis
Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.
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Latest research in brief:
Bowel
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Johnsen PH et al, Lancet Gastroenterol Hepatol. 2018;3(1):17-24
Fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS): This single-center placebo-controlled trial demonstrates significant but moderate symptom relief in FMT-treated IBS patients.
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Beaulieu DB et al, Clin Gastroenterol Hepatol. 2018;16(1):99-105
Use of biologic therapy in pregnant women with inflammatory bowel disease: Vaccination of infants against Haemophilus influenzae and tetanus toxin, based on antibody titers measured when infants were at least 7 months old, does not appear to be affected by in utero exposure to biologic therapy.
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Colombel JF et al, Lancet. 2017;390(10114):2779-89
Therapy algorithms for Crohn’s disease: The CALM study demonstrates that timely escalation with TNF inhibitors on the basis of clinical parameters and biomarkers in patients with early Crohn’s disease results in better clinical and endoscopic outcomes than symptom-driven decisions alone.
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Liver Biliary Tracts
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Park H et al, Hepatology. 2018;67(2):492-504
Chronic hepatitis C and chronic kidney disease (CKD): A recent study demonstrates that a hepatitis C virus (HCV) infection leads to a 27% increased risk of CKD. Additionally, HCV-infected patients had a 2-fold higher risk of membranoproliferative glomerulonephritis and a nearly 17-fold higher risk of cryoglobulinemia. Antiviral therapy reduced the risk of CKD by 30%; interestingly, this association was not significant for all-oral therapy.
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Loomba R et al, Hepatology. 2018;67(2):549-59
New treatment options in non-alcoholic steatohepatitis (NASH): Selonsertib inhibits the apoptosis signal-regulating kinase 1 (ASK1), serine/threonine kinase, selectively, leading to an improvement of inflammation and fibrosis in animal models of NASH. A recent phase 2 trial suggests that selonsertib may reduce fibrosis in patients with NASH and stage 2-3 fibrosis.
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Ogasawara S et al, Hepatology. 2018;67(2):575-85
Transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC): Recent data indicate that prophylactic dexamethasone may reduce typical adverse events of TACE such as fever, anorexia, and nausea/vomiting.
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Oesophagus Stomach Duodenum
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Raehsler SL et al, Clin Gastroenterol Hepatol. 2018;16(2):244-51
Side effects of a gluten-free diet (GFD): Data from the NHANES study indicates that persons on GFD had significantly higher urine concentrations of arsenic and higher blood concentrations of lead, mercury and cadmium than persons not avoiding gluten.
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Yeo YH et al, Gut. 2018;67(1):20-7
First-line Helicobacter pylori eradication therapies in countries with high and low clarithromycin resistance: Meta-analysis reveals that sequential therapy for 14 days and hybrid therapy for ≥ 10 days are the most effective therapies in countries with high and low clarithromycin resistance, respectively.
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Peterli R et al, JAMA. 2018;319(3):255-65
Efficacy of bariatric surgery in patients with morbid obesity: A comparative trial of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass reveals no difference in excess BMI loss after 5 years.
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Pancreas
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Kromrey ML et al, Gut. 2018;67(1):138-45
Prevalence of pancreatic cysts in the general population: This prospective study reveals that cyst prevalence is unexpectedly high and their number and size increase with age. However, only 6% of cysts and 2.5% of the study group initially presented with clinically meaningful cysts of more than 1 cm.
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International Symposia and Workshops
Symposium 210
Crossing New Borders in IBD: Thoughts and Demands – From Mechanisms to Treatment
April 20 – 21, Lisbon, Portugal
Estoril Centro de Congressos, Avenida Amaral, 2765-192 Estoril, Portugal
Registration
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Symposium 211
XXV International Bile Acid Meeting: Bile Acids in Health and Disease 2018
July 6-7, 2018, Dublin, Ireland
Clayton Hotel Burlington Road, Upper Leeson Street, D04 A318 Dublin 4, Ireland
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Current Falk literature:
AInflammatory bowel disease
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Scientific Editor: J. Rasenack
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