Falk Gastro Info 3/2024

Yang Y et al, Am J Gastroenterol. 2024;119(1):138–46

Kidney and urological complications in patients with inflammatory bowel diseases (IBD): More than 10% of patients with IBD developed chronic kidney disorders within 10 years of IBD diagnosis and the risk of acute kidney failure and kidney stones was increased in a Swedish cohort study.

Slooter CD et al, Hepatology. 2024;79(3):538–50

Autoimmune hepatitis: Lack of complete biochemical response leads to adverse outcome: The International Autoimmune Hepatitis Group retrospective registry (IAIHG-RR) represents the world's largest autoimmune hepatitis cohort. A recent evaluation demonstrates that a lack of complete biochemical treatment response is a significant unfavorable prognostic factor (association with liver-related death and liver transplantation). Other, but less strong, negative prognostic factors include non-White ethnicity, cirrhosis, and overlap syndrome with primary sclerosing cholangitis.

Harrison SA et al, N Engl J Med. 2024;390(6):497–509

Non-alcoholic steatohepatitis (NASH) with liver fibrosis: Efficacy of resmetirom in a randomized, controlled phase 3 trial: Resmetirom was superior to placebo with respect to NASH resolution (dose-dependent 26–30% vs. 10% with placebo) and improvement in liver fibrosis by at least one stage (dose-dependent 24–26% vs. 14% with placebo).

Teoh AYB et al, Lancet Gastroenterol Hepatol. 2024;9(2):124–32

Endoscopic ultrasonography-guided gastroenterostomy (EUS-GE) versus uncovered duodenal metal stenting: In patients with malignant gastric outlet obstruction, a randomized trial revealed that EUS-GE can reduce the frequency of reintervention, improve stent patency and result in better patient-reported eating habits.

Liu BD, et al, Gut. 2024;73(2):246–54

Shorter-acting glucagon-like peptide-1 receptor agonists (GLP-1-RAs) and gastroesophageal reflux disease: Therapy with shorter acting GLP-1 receptor agonists was associated with increased risks of gastroesophageal reflux disease and subsequent complications such as strictures and Barrett’s esophagus according to a large cohort study.