Falk Gastro Info 12/2014

Video

 

Video report: Diagnosing extraintestinal celiac disease

 

Presented by:

Dr. Julio C. Bai, Departeamento de Medicina, Hospital de Gastroenterologia, Dr. Carlos Bonorino Udaond, Buenos Aires, Argentinia

 

Summary

Alongside the fact that the disease often has a subclinical course, one of the main reasons why celiac disease is regularly diagnosed so late is the manifestation of extraintestinal symptoms. These symptoms include refractory anaemia, reflux disease, skin conditions like dermatitis herpetiformis and psoriasis, osteopenia and osteoporosis as well as recurrent mouth ulcers, neurological symptoms and a low body weight.

 

Celiac disease is strongly associated with autoimmune diseases. There is a very clear link with dermatitis herpetiformis, an autoimmune disease that causes wheals and blisters. A gluten-free diet will usually clear up the extraintestinal symptoms associated with celiac disease. Within just a few weeks, sufferers can expect to see an improvement in reflux symptoms, psychological abnormalities and gluten ataxia as well as a reduced risk of fractures caused by osteoporosis. Neurological symptoms and osteoporosis, however, take a very long time to improve. Realistically, sufferers will only see progress after following a strict gluten-free diet for some years.

 

Video report of the presentation given by Dr. Julio C. Bai, Buenos Aires, at the Falk Symposium 193 “Celiac disease and other small bowel disorders”, September 5 – 6, 2014 in Amsterdam.

© Falk Foundation e.V., Freiburg. Alle Rechte vorbehalten.

 

Please switch on your loudspeakers!

 

Link to Falk Mediacenter:

http://media.falkfoundation.de/index.php?id=104&L=1

 

Link to the video directly:

http://media.drfalkpharma.de/fileadmin/media/Bai_ENG_V3_mittel.mp4

 

Preview images:

 

180 x 112 pixels

http://www.drfalkpharma.de/fileadmin/media/Video/Bai_180P.jpg

 

580 x 350 pixels

http://www.drfalkpharma.de/fileadmin/media/Video/Bai_580.jpg

 

 

 

 

 

 

 

 

Bowel

 

Text:

Walters TD et al, Gastroenterology. 2014;146(2):383–91

In children newly diagnosed with severe Crohn’s disease, early monotherapy with an anti-TNF-alpha-antibody produced better overall clinical and growth outcomes at 1 year than early monotherapy with an immunomodulator.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27491

 

 

Text:

Osterman MT et al, Gastroenterology. 2014;146(4):941–9

In patients with Crohn’s disease, the incidence of malignancy with adalimumab monotherapy was not greater than that of the general population. However, co-administration of an immunomodulator and adalimumab was associated with an increased risk of non-melanoma skin cancer and other cancers.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27492

 

Text:

Kabbani TA et al, Am J Gastroenterol. 2014;109(5):741–6

The authors have developed an easy and useful diagnostic algorithm to differentiate celiac disease from non-celiac gluten sensitivity.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27493

 

 

 

Liver
Biliary Tracts

 

Text:

van Gerven NMF et al, J Hepatol. 2013;58(1):141–7

Loss of remission or relapse occurs in virtually all patients with autoimmune hepatitis in long-term remission when immunosuppressive therapy is discontinued.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27494

 

 

 

 

 

Text:

Feld JJ et al, N Engl J Med. 2014;370(17):1594–603

In previously untreated patients with hepatitis C virus genotype 1 infection and no cirrhosis, a 12-week multitargeted regimen of ABT-450/r + ombitasvir + dasabuvir + ribavirin was highly effective.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27495

 

 

Text:

Zeuzem S et al, N Engl J Med. 2014;370(17):1604–14

Rates of response to a 12-week interferon-free combination regimen (ABT-450/r + ombitasvir + dasabuvir + ribavirin) were more than 95% among previously treated patients with hepatitis C virus genotype 1 infection, including patients with a prior null response.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27496

 

 

 


 

Oesophagus

Stomach

Duodenum

 

 

Text:

Leggett CL et al, Clin Gastroenterol Hepatol. 2014;12(4):583–8

Obstructive sleep apnea is associated with an increased risk of Barrett’s esophagus, potentially through body mass index and gastroesophageal reflux disease-independent mechanisms.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27497

 

 

Text:

Coleman HG et al, Am J Gastroenterol. 2014;109(4):527–34

Patients with long-segment Barrett’s esophagus or Barrett’s ulcer have an increased risk of progressing to high-grade dysplasia/esophageal adenocarcinoma. The absence of reflux symptoms is not associated with a reduced risk of malignant progression.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27498

 

 

 

Text:

Dellon ES et al, Clin Gastroenterol Hepatol. 2014;12(4):589–96

Eosinophilic esophagitis is frequently diagnosed in the United States, with an estimated prevalence of 57/100,000 persons.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27499

 

 

Pancreas

 

 

Text:

Oskarsson V et al, Clin Gastroenterol Hepatol. 2014;12(4):676–82

Diets with high glycemic load are associated with an increased risk of non-gallstone-related acute pancreatitis.

 

Link:

http://www.drfalkpharma.de/index.php?L=1&id=18864#c27500


 

Current Falk literature:

 

 

Falk Symposium report

Celiac Disease and Other Disorders of the Small Bowel

Amsterdam (The Netherlands), September 5 – 6, 2014

(15 pages)

FSR193e

 

Picture:

http://www.drfalkpharma.de/fileadmin/media/Falk_Veranstaltungen/Falk_Symposium_Report/FR193e.jpg

 

 

PDF:

http://www.drfalkpharma.de/fileadmin/media/Falk_Veranstaltungen/Falk_Symposium_Report/FR193e_Amsterdam_2014.pdf

 

 

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