Falk Gastro Info 1/2016

Video

Video course abdominal ultrasound

Right liver lobe, additional examination

Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.

Please switch on your loudspeakers!

Link to Falk Mediacenter

Latest research in brief:

Bowel

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Yoshimura N et al, Gastroenterology. 2015;149(7):1775–83.e2

Ulcerative colitis: The oral α4-integrin antagonist AJM300 effectively induces clinical response, clinical remission and mucosal healing in patients with moderately active ulcerative colitis.

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Schoen RE et al, Gastroenterology. 2015;149(6):1438–45.e1

Family history of colorectal carcinoma: Tumor risk is only modestly increased in persons at the age above 55 years, if only one first-degree relative is affected.

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Jones JL et al, Clin Gastroenterol Hepatol. 2015;13(13):2233–40.e2

Immunosuppressive therapy of Crohn’s disease: On the basis of a meta-analysis, continued use of immunomodulator therapy after starting anti-TNF therapy is not more effective than anti-TNF monotherapy in inducing and maintaining response and remission.

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Liver Biliary Tracts

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Bosch A et al, J Hepatol. 2015;63(6):1449–58

Primary biliary cholangitis (PBC, formerly primary biliary cirrhosis): The risk of recurrent PBC after liver transplantation can be reduced by preventive treatment with ursodeoxycholic acid (UDCA). Recurrence rates after 10 years were 21% (with UDCA) versus 53% (without UDCA).

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Lammers WJ et al, Gastroenterology. 2015;149(7):1804–12.e4

Primary biliary cholangitis(PBC, formerly primary biliary cirrhosis): The newly developed and validated GLOBE score predicts transplant-free survival of ursodeoxycholic acid-treated patients with PBC. The score is calculated based on patient age as well as the routine laboratory parameters bilirubin, alkaline phosphatase, albumin, and platelet count, determined 1 year after start of ursodeoxycholic acid therapy.

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Hung GY et al, J Hepatol. 2015;63(6):1390–6

Hepatitis B and hepatocellular carcinoma (HCC): 30 years after implementation of the universal hepatitis B immunization program in Taiwan, hepatitis B-associated HCC is nearly eradicated in children and young adults in Taiwan. This good news will hopefully encourage the promotion of hepatitis B vaccination programs in western countries.

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Oesophagus Stomach Duodenum

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Mårild K et al, Am J Gastroenterol. 2015;110(10):1475–84

Risk for celiac disease: A prospective nationwide study shows increased risk for developing celiac disease in children with multiple infections during early life.

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Staerk L et al, BMJ. 2015;351:h5876

Gastrointestinal bleeding in patients with atrial fibrillation: Reinitiation of antithrombotic treatment is associated with better outcomes for mortality and risk of thromboembolism.

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Wang C et al, JAMA. 2015;314(19):2062–8

Parenteral iron therapy: All intravenous iron products examined in a large retrospective study were associated with a low risk of anaphylaxis.

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Pancreas

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Nawaz H et al, Am J Gastroenterol. 2015;110(10):1497–503

Acute pancreatitis: Elevated serum triglycerides are independently and proportionally correlated with persistent organ failure regardless of etiology.

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International Symposia and Workshops

Workshop

Communications and System Relevance in Liver Damage and Regeneration

January 21 – 22, 2016, Düsseldorf, Germany

Building 23.01, Hörsaal 3D, Heinrich-Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany

Program

Registration

Online registration

Symposium 201

Gut-Liver Interactions: From IBD to NASH

March 11 – 12, 2016, Innsbruck, Austria