Dr. Falk Video report
Examination of the kidneys:
Right kidney, topography
Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.
©2019 Falk Foundation e.V., Freiburg. All rights reserved.
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Latest research in brief:
Bowel
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Sands BE et al, N Engl J Med. 2019;381(13):1201–14
Ustekinumab as induction and maintenance therapy for ulcerative colitis: Ustekinumab is more effective than placebo for inducing and maintaining remission in patients with moderate-to-severe ulcerative colitis.
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Sands BE et al, N Engl J Med. 2019;381(13):1215–26
Vedolizumab vs. adalimumab for moderate-to-severe ulcerative colitis: Vedolizumab was superior to adalimumab with respect of achievement of clinical remission and endoscopic improvement, but not steroid-free clinical remission.
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Backes Y et al, Gastroenterology. 2019;157(5):1222–32.e4
Tumor seeding during colonoscopy and metachronous colorectal cancer: In an analysis of primary and secondary tumors from patients with metachronous colorectal cancer the authors found that primary tumor cells might be seeded in a new location after biopsy of the primary tumor by colonization of the working channel with viable tumor cells. However, the risk of iatrogenic tumor seeding appears to be low (0,3–0,6%).
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Liver Biliary Tracts
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Llaneras J et al, J Hepatol. 2019;71(4):666–72
Hepatitis C: Real-world data confirm that the combination of sofosbuvir, velpatasvir and voxilaprevir is an effective and safe rescue therapy for patients with prior failure of direct-acting antivirals (DAAs). Resistance-associated substitutions do not have a relevant impact. Patients with liver cirrhosis and genotype 3, however, remain the most-difficult-to-treat patient group.
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Traussnigg S et al, Lancet Gastroenterol Hepatol. 2019;4(10):781–93
Non-alcoholic fatty liver disease (NAFLD): A current phase 2 trial demonstrates that norursodeoxycholic acid (norUDCA, 1500 mg daily) results in a significant reduction of serum alanine aminotransferase within 12 weeks of treatment. NorUDCA was safe and well tolerated.
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Reverter E et al, J Hepatol. 2019;71(5):942–50
Liver cirrhosis: A current study identified the hepatic venous pressure gradient (HVPG) as a good predictor of morbidity and mortality of extrahepatic surgery in patients with liver cirrhosis. HVPG values > 16 mmHg, especially ≥ 20 mmHg, were associated with a high risk of post-surgical mortality. With an HVPG ≥ 20 mmHg, post-surgical mortality reached 44%.
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Oesophagus Stomach Duodenum
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Wani S et al, Gastrointest Endosc. 2019;90(5):732–41.e3
Quality of biopsy sampling practices for Barrett’s esophagus (BE): Results of a large BE register indicate that endoscopists systematically undersample BE patients in nearly 20% of cases. As BE length increases, endoscopists become less compliant with the Seattle protocol and the odds of non-adherence increases by 31% with every 1-cm increase in length.
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Spechler SJ et al, N Engl J Med. 2019;381(16):1513–23
Medical versus surgical treatment for refractory heartburn: Truly PPI-refractory and reflux-related heartburn occurs only in 21% of patients referred for refractory heartburn. However, fundoplication was superior to medical therapy in that highly selected subgroup.
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Frazzoni M et al, Am J Gastroenterol. 2019;114(10):1606–13
Role of reflux in the pathogenesis of eosinophilic esophagitis (EoE): pH-impedance analysis reveals that reflux is involved in EoE pathogenesis and impedance measurements may be useful to predict refractoriness to proton-pump inhibitors.
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Pancreas
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Yang J et al, Endoscopy. 2019;51(11):1035–43
Lumen-apposing stents (LAMS) versus plastic stents in the management of pancreatic pseudocysts: In this retrospective cohort study LAMS appear to be safe and more effective as compared to double-pigtail plastic stents.
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International Symposia and Workshops
Workshop
Primary Liver Cancer – Emerging Concepts and Novel Treatments
February 13–14, 2020, Mainz, Germany
Philosophicum, Johannes Gutenberg-Universität, Jakob-Welder-Weg 18, 55128 Mainz, Germany
Registration
Online registration
Symposium 218
Current Challenges of Inflammatory Bowel Disease
6.–7. März, 2020, Mexico City, Mexico
Hyatt Regency Hotel, Campos Elíseos 204, Polanco Chapultepec, 11560 Mexico City, Mexico
Registration
Online registration
Current Falk literature:
Crohn’s Disease and Ulcerative Colitis in Children and Adolescents
Author: M. Claasen
in collaboration with: S. Buderus, J. de Laffolie, A. Enninger, M. Melter,
C. Posovszky, B. Rodeck
(132 pages)
S4e