Video course abdominal ultrasound
Examination of the abdominal vessels – Celiac trunk
Author: Prof. Dr. Christoph F. Dietrich ©2019 Falk Foundation e.V., Freiburg. All rights reserved.
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Bowel
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Kobayashi T et al, Lancet Gastroenterol Hepatol. 2021;6(6):429–37
Relapse following discontinuation of infliximab in patients with ulcerative colitis: Results of a randomized controlled trial indicate that patients with discontinued infliximab therapy have a relapse rate of 45,7% within 48 weeks as compared to 19,6% in patients receiving continued infliximab therapy.
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Khan N et al, Gastroenterology. 2021;161(3):827–36
Effectiveness of SARS-CoV2 vaccination in patients with inflammatory bowel diseases (IBD): A large cohort study of veterans with IBD reveals that full vaccination has an 80,4% effectiveness in a broad population with diverse exposure to immunosuppressive therapies.
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Verhaegh BPM et al, J Crohns Colitis. 2021;15(7):1174–83
Disease course in patients with microscopic colitis: Results of a large European inception cohort indicate that a minority of patients with microscopic colitis follow a quiescent disease course whereas the majority suffers from chronic active or relapsing disease with significantly impaired quality of life.
Liver Biliary Tracts
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Younes R et al, J Hepatol. 2021;75(4):786–94
Non-alcoholic fatty liver disease (NAFLD): There are numerous non-invasive scoring systems for predicting fibrosis in patients with NAFLD. A current study examined the predictive power of these scores for the long-term outcome (risk of fibrosis, liver-related complications, or death). The NAFLD fibrosis score (NFS), hepamet fibrosis score (HFS) and fibrosis 4 index (FIB-4) performed best.
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Cristoferi L et al, Hepatology. 2021;74(3):1496–508
Primary biliary cholangitis (PBC): Accuracy of transient elastography at diagnosis of PBC (and thus in naive patients) has not been defined. A current study demonstrates that advanced fibrosis can indeed be excluded (liver stiffness measurement ≤ 6.5 kPa) or confirmed (> 11.0 kPa) in many patients in this setting using transient elastography. However, transient elastography is not reliable between these 2 cut-offs, and a liver biopsy may be necessary. BMI and liver biochemistry did not affect transient elastography.
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Mallet V et al, J Hepatol. 2021;75(4):848–55
COVID-19 and liver disease: A recent study reveals that chronic liver disease increased the risk of COVID-19-related death in France in 2020. Therapeutic effort limitation may have contributed to COVID-19-related death in patients with a liver-related complication or an alcohol use disorder.
Oesophagus Stomach Duodenum
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Mégraud F et al, Gut. 2021;70(10):1815–22
Helicobacter pylori resistance to antibiotics: European study confirms higher resistance against clarithromycin and levofloxacin in Central/Western and Southern as compared to Northern Europe, which correlates with higher consumption of macrolides and quinolones. These findings should be considered when choosing eradication therapies.
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Eluri S et al, Endoscopy. 2021;53(9):886–92
Endoscopically normal findings in patients with eosinophilic esophagitis (EoE): Approximately 10% of 878 patients with symptomatic EoE had macroscopically normal endoscopic findings, indicating that macroscopically normal findings should not preclude biopsies.
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Smyth EC et al, Gut. 2021;70(9):1632–41
Epidermal growth factor receptor (EGFR) amplification and outcome in a randomized phase III trial of chemotherapy and panitumumab: EGFR copy numbers were accurately measured in tumor tissues and liquid biopsies and may be used to predict response to chemotherapy and prognosis.
Pancreas
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Akshintala VS et al, Lancet Gastroenterol Hepatol. 2021;6(9):733–42Prevention of post-ERCP pancreatitis: A meta-analysis involving 55 trials and 17,062 patients revealed that rectal diclofenac (100 mg) was the best performing rectal non-steroidal anti-inflammatory drug. Combinations with intravenous fluid therapies or pancreatic stenting may further increase the efficacy.
Symposia 227
Pathophysiology and Clinical Management of Alcoholic Liver Disease
January 27 – 28, 2022, Mannheim, Germany
Barockschloss Mannheim, Room SO 108, Bismarckstraße, Schloss Mittelbau, 68161 Mannheim, Germany
Online registration
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