Dr. Falk Video report
Anti-fibrotic agents in IBD
Video report presented by Prof. Dr. Gerhard Rogler, Zurich, Switzerland at the Symposium 214 “IBD: From Pathophysiology to Personalized Medicine”, March 29–30, 2019 in Oxford, United Kingdom. © Falk Foundation e.V., Freiburg. All rights reserved.
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Latest research in brief:
Bowel
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Wang P et al, Gut. 2019;68(10):1813–9
Real-time automatic adenoma detection in screening colonoscopy:: In a low prevalent Chinese population, an automated polyp detection system based on artificial intelligence resulted in a significant increase in the adenoma detection rate due to increased detection of small diminutive adenomas.
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Chavarría C et al, J Crohns Colitis. 2019;13(8):996–1002
Prevalence and factors associated with fatigue in patients with inflammatory bowel diseases: Results of a prospective multicenter trial from Spain indicate that the prevalence of fatigue was high (41%) and has a negative impact on quality of life. Risk factors for fatigue included anxiety, depression, sleep disturbances, presence of extraintestinal manifestation and therapy with systemic corticosteroids.
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Yamashina T et al, Gastroenterology. 2019;157(2):451–61.e2
Comparison of underwater vs. conventional endoscopic mucosa resection (EMR): In a multicenter trial from Japan underwater EMR significantly increased the proportions of R0 and en bloc resections of intermediate polyps with a size between 10 mm and 20 mm as compared to conventional EMR without increasing adverse events or procedure time.
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Liver Biliary Tracts
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Parker R et al, J Hepatol. 2019;71(3):586–93
Alcohol-related liver disease (ALD): A current systematic review confirms that alcohol-related steatohepatitis requiring admission to hospital is the most dangerous subtype of ALD. Even alcohol-related steatosis is not a benign condition as it is associated with significant risk of mortality.
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van Aerts RMM et al, Gastroenterology. 2019;157(2):481–91.e7
Polycystic liver disease: A current randomized trial of patients with polycystic liver disease due to autosomal dominant polycystic kidney disease (ADPKD) demonstrates that lanreotide for 120 weeks reduced the growth of liver and combined liver and kidney volume. This effect was still present 4 months after the last injection of lanreotide.
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Huh CW et al, Dig Liver Dis. 2019;51(7):993–8
Acute variceal bleeding: In patients with acute variceal bleeding, endoscopic treatment is recommended within 12 hours. A current retrospective study, however, suggests that urgent endoscopy may be significantly associated with poorer outcome especially in low-risk patients. New algorithms might be necessary to define the optimal timing of endoscopy according to the severity of the underlying liver disease.
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Oesophagus Stomach Duodenum
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Schuetz P et al, Lancet. 2019;393(10188):2312–21
Nutrition in medical inpatients: The use of individualized nutritional support during the hospital stay improves important clinical outcomes including survival compared with standard hospital food.
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Fritscher-Ravens A et al, Gastroenterology. 2019;157(1):109–18.e5
Atypical food allergy in patients with irritable bowel syndrome: Results of a translational study using laser endomicroscopy reveal that more than 50% of IBS patients suffer from non-classical and non-IgE-mediated atypical food allergies, in which allergen exposure results in disruption of the intestinal barrier.
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Lucendo AJ et al, Gastroenterology. 2019;157(1):74–86.e15
Induction therapy for eosinophilic esophagitis (EoE): In a randomized trial of 88 adults with active EoE, therapy with budesonide orodispersible tablets for 6 or 12 weeks was highly effective to induce clinical and histological remission as compared to placebo.
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Pancreas
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Lee AA et al, Am J Gastroenterol. 2019;114(7):1163–71
Prevalence of small intestinal bacterial overgrowth (SIBO) in patients with chronic pancreatitis: SIBO occurs in 40.8% of patients with chronic pancreatitis without previous surgery of the upper gastrointestinal tract. Markers of more severe disease including zinc deficiency, diabetes and an increased Mayo score as well as opiate use should raise clinical suspicion for SIBO, particularly in patients with persistent steatorrhea or weight loss despite pancreatic enzyme replacement therapy.
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International Symposia and Workshops
Workshop
Workshop on Nutrition and Microbiome in Allogeneic Haematopoietic Stem Cell Transplantation
November 8–9, 2019, Regensburg, Germany
University Hospital Regensburg, Großer Hörsaal, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
Registration
Online registration
Symposium 217
West Meets East: Functional Meets Organic in Gastrointestinal Diseases
November 29–30, 2019, Singapore, Singapore
Parkroyal on Beach Road, 7500 Beach Road, Singapore, Singapore
Registration
Online registration
Current Falk literature:
Primary biliary cholangitis (PSC)
Compiled by: T. Berg, T. Herta
(31 pages)
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