Falk Gastro Info 10/2022

Video course abdominal ultrasound

CT and MRI in Inflammatory Bowel Disease

Karin Horsthuis, Amsterdam
On-demand video of the lecture from July 7, 2022
Duration: ca. 21:19 min

Symposium 228
Abdominal Imaging in Gastroenterology and Hepatology
Session II: Inflammatory Bowel Disease
Chairs: K. Gecse, Amsterdam; A. Koch, Rotterdam
©Falk Foundation e.V., Freiburg. All rights reserved.

Please switch on your loudspeakers!
Link to Falk Mediacenter
Latest research in brief:
Image
Colon to Rectum
Text:
Odufalu FD et al, Gut. 2022;71(9):1766–72

Pregnancy outcomes among infants of mothers with inflammatory bowel disease (IBD) exposed to corticosteroids: According to a large prospective registry of pregnant IBD patients offspring of women with IBD exposed to corticosteroids during pregnancy is more likely to experience adverse perinatal outcomes including preterm birth, low birth weight and admission to neonatal intensive care units.

Link to Falk Mediacenter
Image
Liver and Bile Ducts
Text:
Biewenga M et al, Clin Gastroenterol Hepatol. 2022;20(8):1776–83.e4

Autoimmune hepatitis type 1: Aminotransferases during treatment predict long-term survival: A recent Dutch study shows that low aspartate aminotransferase after 6, 12, 24 or 36 months of treatment is a good prognostic marker in autoimmune hepatitis type 1. In contrast, immunoglobulin G level during treatment was not associated with survival.

Link to Falk Mediacenter
Text:
Malik AK et al, Eur J Gastroenterol Hepatol. 2022;34(10):1060–6

Repair of symptomatic umbilical hernias in patients with cirrhosis remains a high-risk intervention: In particular, patients with a Model of End-stage Liver Disease (MELD) score > 15 or hyponatremia have a poor prognosis. Emergency operations are associated with a high rate of decompensation and longer hospital stays. Placement of a transjugular intrahepatic portosystemic shunt (TIPS) may improve prognosis, however, further prospective studies need to confirm this finding.

Link to Falk Mediacenter
Text:
Pelizzaro F et al, Dig Liver Dis. 2022;54(7):927–36

Surveillance for hepatocellular carcinoma (HCC) in high-risk patients: No benefit of a 3-months interval:A recent Italian study confirms that a shortened HCC surveillance interval of 3 months compared to 6 months has no benefit regarding early diagnosis, feasibility of curative treatment, or survival.

Link to Falk Mediacenter
Image
Esophagus to Small Intestine
Text:
Chey WD et al, Gastroenterology. 2022;163(3):608–19

Vonoprazan-based therapy for Helicobacter pylori infection: Triple therapies containing the potassium-competitive acid blocker vonoprazan were superior to proton-pump inhibitor-based triple therapy in clarithromycin-resistant strains and in the overall study population in a randomized phase 3 trial performed in the US and in Europe.

Link to Falk Mediacenter
Text:
Jastreboff AM et al, N Engl J Med. 2022;387(3):205–16

Treatment of obesity with tirzepatide: In a 72-week trial, injection of 5 mg, 10 mg or 15 mg of the glucagon-like peptide 1 receptor agonist tirzepatide once weekly provided substantial and sustained reductions in body weight in a randomized phase 3 trial.

Link to Falk Mediacenter
Text:
Sands BE et al, Lancet. 2022;399(10342):2200–11

Head-to-head comparison of ustekinumab and adalimumab in Crohn’s disease: Both ustekinumab and adalimumab monotherapies were highly effective in a phase 3b trial involving biologic-naive patients with moderately to severely active Crohn’s disease (SEAVUE), with no difference in the primary end point of clinical remission.

Link to Falk Mediacenter
Image
Pancreas
Text:
Onnekink AM et al, Gastroenterology. 2022;163(3):712–22.e14

Endoscopic versus surgical step-up approach for infected necrotizing pancreatitis: Long-term follow-up of a randomized trial (TENSION) indicates that endoscopic therapy was not superior to a surgical approach in reducing death or major complications. However, endoscopically treated patients developed fewer pancreaticocutaneous fistulas and needed fewer reinterventions.

Link to Falk Mediacenter

Event

Symposium 230

State-of-the-Art Management of IBD: Current Realities and Future Horizons

November 25 – 26, 2022, Frankfurt, Germany

Kap Europa, Osloer Str. 5, 60327 Frankfurt, Germany

Program
Online registration

Symposium 230

Time for the liver – chronobiology, aging, and current matters in hepatology

January 26 – 27, 2023, Bochum, Germany

Veranstaltungszentrum der RUB Bochum, Universitätsstr. 150, 44801 Bochum, Germany

Program
Online registration

Current Falk literature:

Severe Liver Diseases and Liver Transplantation

Author: K. Herzer

(29 pages)

U13e