Dr. Falk Video report
Examination of the kidneys: Left kidney, different levels
Author: Prof. Dr. Christoph F. Dietrich, Caritas Krankenhaus Bad Mergentheim.
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Latest research in brief:
Bowel
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Frolkis AD et al, Gut. 2019;68(9):1606–12
Depression as risk factor for inflammatory bowel diseases (IBD): Results of a large cohort study indicate that depression increases the risk to develop IBD which is mitigated through treating depression with antidepressants.
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Aroniadis OC et al, Lancet Gastroenterol Hepatol. 2019;4(9):675–85
Fecal microbiota transfer (FMT) to treat irritable bowel syndrome with diarrhea (IBS-D): ): In a placebo-controlled randomized trial involving 48 patients, FMT was safe, but did not improve symptom relieve at 12 weeks as compared with placebo.
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Levine A et al, Gastroenterology. 2019;157(2):440–50.e8
Novel diet to treat children with Crohn’s disease: A novel diet comprising whole food diet and enteral formula nutrition is better tolerated and equally effective as exclusive enteral nutrition after 6 weeks and demonstrated superior sustained remission and reduction in inflammation after 12 weeks.
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Liver Biliary Tracts
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Harms MH et al, J Hepatol. 2019;71(2):357–65
Primary biliary cholangitis (PBC): A current multicenter cohort study demonstrates that ursodeoxycholic acid prolongs the transplant-free survival in patients with PBC. Indeed, the 10-year transplant-free survival was approx. 80% versus approx. 60% in patients without treatment. This benefit of ursodeoxycholic acid was independent of disease stage and observed biochemical response.
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Hajifathalian K et al, Hepatology. 2019;70(2):511–21
Non-alcoholic fatty liver disease (NAFLD): A prospective cohort study from the US demonstrates that modest alcohol consumption is associated with significant decrease in mortality in patients with NAFLD. Drinking 1.5 drinks per day or more, however, is associated with an increase in mortality.
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Chen CJ et al, J Gastroenterol Hepatol. 2019;34(7):1143–52
Sarcopenia in liver cirrhosis: A current meta-analysis demonstrates that late evening snacks can improve liver function reserve for patients with liver cirrhosis, with or without hepatocellular carcinoma. They have a positive effect on liver function parameters (albumin, ammonia, prothrombin time) and transaminases, as well as complications of cirrhosis (ascites, hepatic encephalopathy).
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Oesophagus Stomach Duodenum
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Andrén Aronsson C et al, JAMA. 2019;322(6):514–23
Impact of gluten consumption on risk of celiac disease: Results of the prospective TEDDY trial indicate that intake of gluten during the first 5 years of age is associated with increased celiac disease autoimmunity and celiac disease in children with increased risk.
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Ponds FA et al, JAMA. 2019;322(2):134–44
Initial therapy for achalasia: Results of a randomized trial indicate that peroral endoscopic myotomy (POEM) results in significantly higher treatment success after 2 years as compared to pneumatic dilatation, but results in higher rates of reflux symptoms.
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Moayyedi P et al, Gastroenterology. 2019;157(2):403–12.e5
Pantoprazol to prevent gastrointestinal events in patients receiving rivaroxaban and/or aspirin: Results of this large trial of more than 17.000 patients indicate that routine use of pantoprazole did not reduce upper gastrointestinal events, but resulted in a significant reduction of bleeding events. However, these events occurred rarely and the number needed to treat was therefore very high.
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Pancreas
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Rustgi SD et al, Clin Gastroenterol Hepatol. 2019;17(8):1580–6.e4
Preoperative management of patients with pancreatic cancer: Results of a large American cohort study indicate that preoperative endoscopic retrograde pancreatography before surgery does not have an increased risk of death compared to patients who proceeded directly to surgery.
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International Symposia and Workshops
Workshop
Workshop on Nutrition and Microbiome in Allogeneic Haematopoietic Stem Cell Transplantation
November 8–9, 2019, Regensburg, Germany
University Hospital Regensburg, Großer Hörsaal, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
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Symposium 217
West Meets East: Functional Meets Organic in Gastrointestinal Diseases
November 29–30, 2019, Singapore, Singapore
Parkroyal on Beach Road, 7500 Beach Road, Singapore, Singapore
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Current Falk literature:
GastroScope
Symposium 214
IBD: From Pathophysiology to Personalized Medicine
Oxford (Great Britain)
March 29 – 30, 2019
Issue 01/2019
(23 pages)
GS214e