Examination of the pancreas: Pancreas mobile
Author: Prof. Dr. Christoph F. Dietrich
©Falk Foundation e.V., Freiburg. All rights reserved.
The intestinal adsorbent enterosgel for the treatment of irritable bowel syndrome with diarrhea (IBS-D):Enterosgel was safe and effective in IBS-D in a randomized placebo-controlled trial involving 440 patients and may provide an alternative to the limited current treatment options for IBS-D.
Kedia S et al, Gut. 2022;71(12):2401–13
Fecal microbiota transfer (FMT) with anti-inflammatory diet to treat ulcerative colitis: Multidonor FMT with anti-inflammatory diet effectively induced deep remission in mild-to-moderate ulcerative colitis which was sustained with anti-inflammatory diet alone over 1 year.
Yuen MF et al, N Engl J Med. 2022;387(21):1957–68
Drug pipeline for chronic hepatitis B: Antisense oligonucleotide bepiroviruses leads to impressive reduction of HBsAg and HBV-DNA. In a recent phase 2b study, 9–10% of participants achieved sustained HBsAg and HBV DNA loss after just 24 weeks of therapy.
João M et al, Dig Liver Dis. 2022;54(12):1681–5
Identification of patients with severe acute autoimmune hepatitis who do not respond to steroids and need urgent liver transplantation. Severe acute autoimmune hepatitis remains a critical situation as some patients do not respond to steroids and thus require urgent liver transplantation. A recent study identifies two scores that predict early which patients will not respond to steroids and therefore need urgent liver transplantation.
Xu T et al, Eur J Gastroenterol Hepatol. 2023;35(1):80–8
Meta-analysis of randomized controlled trials of albumin administration in cirrhosis with ascites: no reduction in mortality, but risk of pulmonary edema. Albumin administration in patients with cirrhosis and ascites is discussed controversially due to contradictory study results. A recent meta-analysis of randomized controlled trials concludes that albumin administration cannot reduce mortality, but is associated with the risk of pulmonary edema.
Efficacy of Latiglutenase in patients with celiac disease exposed to a gluten challenge: G-In this phase 2 trial, latiglutenase (IMGX003) reduced gluten-induced intestinal mucosa damage and symptom severity as compared to placebo.
Long-term natural history of autoimmune gastritis in Helicobacter pylori naive patients: Oxyntic-restricted inflammation and enterochromaffin-like cell hyperplasia/dysplasia are hallmarks of autoimmune gastritis. However, compared to the general population, autoimmune gastritis in these patients does not result increased risk for gastric cancer.
Comparison of lumen-apposing metal stents (LAMS) versus double-pigtail plastic stents for infected necrotizing pancreatitis:A comparison of 2 prospectively collected patient cohorts suggests that LAMS do not reduce the need for transluminal endoscopic necrosectomy and yield a similar risk of bleeding complications.
Time for the liver – chronobiology, aging, and current matters in hepatology
January 26 – 27, 2023, Bochum, Germany
RUB Convention Centre, Universitätsstr. 150, 44801 Bochum, Germany
Inflammation of the Upper and Lower GI Tract: Common mechanisms and Treatments or Important Differences?
April 28 – 29, 2023, Bordeaux, France