Falk Gastro Info 7/2025

Ho FF et al, Aliment Pharmacol Ther. 2025;61(9):1519-1531

Healthy lifestyle protects against inflammatory bowel diseases (IBD): Healthy lifestyle behaviours (never smoking, optimal sleep, high level of vigorous physical activity, high dietary quality, and moderate alcohol intake) were significantly associated with lower IBD incidence in middle-aged and elderly individuals in this prospective population-based cohort study, suggesting the potential of lifestyle modifications as a primary prevention strategy for IBD.

Jeppesen PB et al, Gastroenterology. 2025;168(4):701-713.e6

Glepaglutide, a novel long-acting GLP-2 analogue for short bowel syndrome: Biweekly or weekly injections of glepaglutide resulted in substantial benefits of patients with intestinal failure and resulted in clinically relevant reduction of parenteral support as compared to placebo in this phase 3 trial.

Odisio BC et al, Lancet Gastroenterol Hepatol. 2025;10(5):442-451

Software- and AI-based control of ablative margins in thermal ablation of liver tumours demonstrates advantages over visual assessment: After enroling just 50 patients with liver tumours of various etiologies, significantly larger ablative margins were observed in the AI-assisted control group, halting the enrolment of patients in the control group. The significant improvement in the minimal ablative margin could improve local tumour control and reduce the risk of recurrence.

Wang Y et al, J Hepatol. 2025;82(5):871-881

The PNPLA3 mutation, which is associated with a significantly increased risk of developing steatotic liver disease, is a gain-of-function mutation: This study shows that the PNPLA3(148M) mutation contributes to hepatic steatosis by inhibiting hepatic lipolysis. Reducing PNPLA3 expression could therefore be a component of future treatment strategies for steatotic liver disease.

Zhang Y et al, JAMA Intern Med. 2025;185(5):549-560

Butter and plant-based oils intake and mortality: In this cohort study, higher intake of butter was associated with increased mortality, while higher plant-based oils intake was associated with lower mortality. Substituting butter with plant-based oils may therefore confer substantial benefits for preventing premature deaths.

Bokemeyer B et al, J Crohns Colitis. 2025;19(4):jjaf051

Comparative real-world effectiveness (RWE) of ustekinumab vs. anti-TNF in Crohn's disease: In this 12-month RWE comparison, overall clinical remission rates were similar between ustekinumab and anti-TNF. However, among week-16 responders, remission rates were significantly higher with ustekinumab. In addition, ustekinumab was associated with a significantly greater improvement in quality of life compared with anti-TNF.