Dr. Falk Video report
EoE – State of the Art – PART 2
Video-Report – PART 2 of the Satellite Symposium „EoE – State of the Art“, which took place during the ueg week 2018 in Vienna (Austria). Dr. Arjan Bredenoord from Amsterdam (The Netherlands) talked about “Epidemiology and Pathogenesis” of Eosinophilic Esophagitis.
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Latest research in brief:
Bowel
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Crockett SD et al, Gut. 2019;68(3):475–86
Calcium and vitamin D supplementation and risk of serrated polyps: A placebo-controlled chemoprevention trial reveals that supplementation with calcium or calcium/vitamin D is associated with a 2.7- and 3.8-fold increased risk for the development of sessile serrated adenoma and polyps. Increased risk was a late effect observed 6–10 years after initiation of supplementation.
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Sahami S et al, J Crohns Colitis. 2019;13(2):165–71
Appendectomy for therapy-refractory ulcerative colitis: Results of a pilot study involving 30 patients suggest that appendectomy may be effective in 30% of patients, which correlated with active inflammation within the appendix, suggesting that a subgroup of ulcerative colitis patients may benefit substantially from appendectomy.
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Vleugels JLA et al, Gastroenterology. 2019;156(3):623–34.e3
Colon cancer screening: Diminutive polyps with advanced histologic features do not increase risk for metachronous advanced colon neoplasia.
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Liver Biliary Tracts
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Wedemeyer H et al, Lancet Infect Dis. 2019;19(3):275–86
Hepatitis D: The current standard of care for chronic HDV/HBV infection is a 48-week course of pegylated interferon-α, leading to HDV clearance in 25–30% of patients only. The recently published HIDIT-II study demonstrates that neither a treatment prolongation to 96 weeks nor the combination with tenofovir is of substantial benefit.
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Carrat F et al, Lancet. 2019;393(10179):1453–64
Hepatitis C: A current prospective cohort study from France including 9895 patients (3/4 treated during the follow-up, 1/4 untreated) demonstrates that treatment with direct-acting antivirals (DAA) is associated with a markedly reduced risk of mortality and hepatocellular carcinoma. The risk for decompensated cirrhosis, however, was not affected by DAA treatment in this cohort.
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Heffernan A et al, Lancet. 2019;393(10178):1319–29
Hepatitis C: A current global mathematical model reveals that further improvements in blood safety and infection control, expansion of creation of harm reduction services for people who inject drugs, and extensive screening for hepatitis C virus (HCV) with concomitant treatment for all are necessary to reduce the burden of HCV. Only a consequent implementation of these measures will allow to reach the WHO aims (HCV incidence reduction of 80% and mortality reduction of 65% by 2030).
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Oesophagus Stomach Duodenum
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Faye AS et al, Clin Gastroenterol Hepatol. 2019;17(3):463–8
Screening for celiac disease among family members: Nearly 30% of symptomatic first-degree relatives of patients with celiac disease in an American center have not received the tests for celiac disease recommended by current guidelines.
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Hirano I et al, Gastroenterology. 2019;156(3):592–603.e10
Biological therapy for eosinophilic esophagitis (EoE): The monoclonal anti-IL-13 antibody RPC4046 reduced histologic and endoscopic features of EoE compared with placebo in a phase 2 trial.
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den Hollander WJ et al, Gut. 2019;68(4):585–93
Screening for gastric cancer in low incidence regions: A prospective trial from the Netherlands and Norway indicates that patients with atrophic gastritis, intestinal metaplasia or dysplasia have a neoplastic progression rate of 0.3% per year. Endoscopic surveillance programs can detect cancer at an early and curable stage.
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Pancreas
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Corral JE et al, Clin Gastroenterol Hepatol. 2019;17(1):41–53
ening of asymptomatic individuals at high-risk for pancreatic cancer: Meta-analysis reveals that 135 patients must be screened by endosonography or magnetic resonance imaging to identify 1 patient with a high-risk pancreatic lesion. These findings raise the question whether such screening approaches are reasonable and cost-effective.
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International Symposia and Workshops
Symposium 215
IBD: From Diagnosis to Therapy
July 5–6, 2019, St. Petersburg, Russia
Park Inn by Radisson, Pribaltiyskaya, Ul. Korablestroiteley 14, 199226 St. Petersburg, Russia
Registration
Online registration
Current Falk literature:
WColon Diverticulosis and Diverticulitis
Author: B. Lembcke
(64 pages)
M4e